Calimmune Inc , a clinical-stage gene therapy company has successfully completed its 15 million Series B financing round led by a large pharmaceutical company Alexandria Venture Investments also joined with existing investors including RA Capital Healthcare Fund LP and Translational Accelerator LLC Proceeds will be used to progress the company’s ongoing HIV/AIDS clinical trials advanced technology research programs and general corporate operations
Over the past several decades HIV/AIDS has shifted from a deadly disease to one that can largely be managed with medication The next logical step in the evolution of HIV/AIDS patient care is finding a cure by enhancing the body’s own defenses ‘
Cal-1 the company’s lead therapeutic candidate is a gene-based therapy engineered to control HIV infection and to protect individuals with HIV from progressing to AIDS The therapy is currently being evaluated in Phase I/II studies Cal-1 is designed to reduce production of CCR5 a protein on the surface of white blood cells that plays a critical role in enabling HIV to infect cells It also has a second mechanism aimed at preventing viral fusion the process by which the virus enters the cell This dual approach was shown to be effective against broad strains of HIV in pre-clinical studies
In clinical trials for Cal-1 volunteers with HIV are infused with their own blood stem cells as well as mature T cells that have been treated with Cal-1 By reducing CCR5 expression and preventing HIV viral fusion Cal-1 may protect the treated cells against HIV and has the potential to provide a continuous means of controlling HIV after a single treatment The initial study sites are Quest Clinical Research in San Francisco and The UCLA CARE Center
Calimmune has assembled a world-class team and a comprehensive technology arsenal that harnesses the power of gene therapy to combat HIV and potentially a wide range of challenging diseases said Peter Kolchinsky Ph D , managing partner at RA Capital
We are inspired by the support of such a high-caliber group of investors who share in our vision to provide enduring perhaps lifelong benefits to patients whose daily lives are severely compromised by currently incurable devastating diseases said Louis Breton chief executive officer of Calimmune Over the past several decades HIV/AIDS has shifted from a deadly disease to one that can largely be managed with medication The next logical step in the evolution of HIV/AIDS patient care is finding a cure by enhancing the body’s own defenses ‘
The primary objectives of the Phase I/II trial for Cal-1 are to assess safety determine the ease of use and feasibility for individuals living with HIV and evaluate what if any side effects may exist
According to the World Health Organization some 35 million people are living with HIV/AIDS worldwide In the United States the number of people living with HIV/AIDS exceeds 1 2 million Infection with the human immunodeficiency virus HIV can lead to acquired immunodeficiency syndrome AIDS a disease that severely impairs immune function and leaves the body vulnerable to numerous secondary infections and complications
About Calimmune
Calimmune Inc is a clinical-stage biotechnology company focused on developing novel gene therapies that have the potential to improve and protect the lives of patients by enhancing their immune systems The company was founded in 2006 from technology developed in the labs of Nobel Laureate David Baltimore Ph D California Institute of Technology Irvin Chen Ph D University of California Los Angeles and Inder M Verma Ph D Salk Institute for Biological Studies Calimmune’s lead product candidate for HIV now in Phase I/II studies is being evaluated as a one-time treatment to prevent HIV progression to AIDS Calimmune is developing a full product pipeline of therapeutic candidates to address the unique needs of individuals at different stages of HIV infection and with various treatment histories The company is headquartered in Tucson Arizona with labs and branch offices in Pasadena California and Sydney Australia
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